Seroconversion to hepatitis C virus alternate reading frame protein during acute infection

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Seroconversion to hepatitis C virus alternate reading frame protein during acute infection.

UNLABELLED The existence of hepatitis C virus (HCV) proteins encoded by alternate reading frames overlapping the core-encoding region has been suggested. Several mechanisms of production have been postulated, and the functions of these proteins in the HCV life cycle remain unknown. We analyzed cases of seroconversion to an alternate reading frame protein in a group of 17 patients infected by on...

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Hepatitis C virus (HCV) is a human RNA virus encoding 10 proteins in a single open reading frame. In the +1 frame, an 'alternate reading frame' (ARF) overlaps with the core protein-encoding sequence and encodes the ARF protein (ARFP). Here, we investigated the molecular regulatory mechanisms of ARFP expression in HCV target cells. Chimeric HCV-luciferase reporter constructs derived from the inf...

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ژورنال

عنوان ژورنال: Hepatology

سال: 2009

ISSN: 0270-9139

DOI: 10.1002/hep.22821